Protecting beta cells against stress may guard against type 1 diabetes was discussing on the Joslin Diabetes Center newsletter, 27 July 2020.
Joslin Diabetes Center researchers, working with mouse models and in human cells, has shown that targeting a protein called renalase may protect beta cells against autoimmune attack by strengthening them against stress, says Stephan Kissler, an investigator in Joslin’s Section on Immunobiology, associate professor of medicine at Harvard Medical School, and co-senior author on a paper describing the work in Nature Metabolism. Kissler, co-senior author Peng Yi, PhD, and their colleagues also demonstrated that an existing FDA-approved drug inhibits renalase and increases the survival of beta cells in those lab models.
The Joslin study joins a growing set of evidence suggesting that functional problems with beta cells themselves may help to trigger the autoimmune attack in type 1 diabetes, say Kissler and Yi, who is an assistant investigator in the Islet Cell and Regenerative Biology Section. “You might have genes that make the beta cell a little bit dysfunctional and more prone to becoming a target of the immune system,” Kissler explains.
TCOYD’s ONE: The Ultimate Virtual Conference Exerience for Adults with T1D, FREE … 3 October 2020.
Join TCOYD Founder & Director Dr. Steve Edelman and his first-class team of type 1 docs and diabetes specialists for a TRANSFORMATIVE DAY. We throw out the sterile, grey, clinical setting and bring your learning experience WHEREVER YOU ARE IN THE WORLD. What to expect: Inspiring speakers, empowering educational lectures, motivating workshops, one-on-one sessions with the pros, an interactive innovative health fair. CHANGE THE WAY YOU LIVE WITH TYPE 1.
WHEN: SATURDAY, OCTOBER 3, 2020, 8am – 6pm PDT
WHERE: This event will be hosted on a virtual conference platform called vFairs, which is accessible through any internet browser. All registered participants will receive a link via email to join the event.
HOW MUCH: This event is complimentary.
Here’s the program details: ONE: The Ultimate Virtual Conference for Adult T1Ds
To register: ONE Registration