Why Apple And Google Are Working On Diabetes Tech was posted by CNBC, 31 July 2019.

Apple and Alphabet are moving into the health care. Both companies have been rumored to be working on non-invasive ways to check blood glucose levels but never bought anything to market. Now, both tech giants are collaborating with medical device company Dexcom, a maker of continuous glucose monitors for people with diabetes. CNBC got an inside look at the innovation behind Dexcom’s latest CGM and its manufacturing process to better understand why two of the world’s biggest tech companies are partnering with it.

Whole-body vibration changes the microbiome, lowers inflammation was reported by Ana Sandoiu for MedicalNewsToday.com, 5 August 2019. A new study in mice reveals the beneficial effects of whole-body vibration on inflammation and the microbiome. I’ve seen folks shaking on these machines at the gym but I couldn’t understand why!  Now I understand!

Whole-body vibration (WBV) is a form of passive exercise that first appeared in the late 1990s and gained popularity in the last decade as a form of fitness training. WBV requires a person to stand on a platform that typically vibrates at a frequency of 15–70 hertz (Hz) and an amplitude of 1–10 millimeters (mm). The human body automatically adapts to “repeated, rapid, and short intermittent exposure to oscillations” from this type of vibrating platform, which prompted researchers to classify WBV as a “light neuromuscular resistance training method.”

Some studies have shown that WBV improves muscle performance, bone density, strength, and balance, as well as helping to reduce body fat in the long term. Importantly, previous research has also shown that WBV can reduce inflammation and even “reverse many symptoms” of type 2 diabetes, such as frequent urination and excessive thirst. Research indicates that it also improves blood sugar control and insulin resistance, as measured by the standard glucose tolerance test and the hemoglobin A1C blood sugar test.

Dr. Jack Yu, head of pediatric plastic surgery and fellow researchers from the Medical College of Georgia (MCG) and the Dental College of Georgia (DCG), at Augusta University, reported their study — which appears in the International Journal of Molecular Sciences— together with Dr. Babak Baban, immunologist and interim associate dean for research at DCG.

Conceptual illustration of human microbiome as collection of microbes.

Furthermore, the experiments revealed that WBV resulted in an increase in M2 macrophages — immune cells that suppress inflammation — as well as increases in anti-inflammatory cytokines, such as interleukin-10, both in mice that had diabetes and in healthy mice. In fact, in the mouse model of diabetes, WBV brought M2 levels back to those of healthy control mice.

Finally, the researchers wanted to see whether giving the mice small doses of Alistipes as a medication and combining it with a shorter session of WBV would have a therapeutic effect.  As soon as the population of this gut bacterium increased, the ratio between pro-inflammatory M1 macrophages and anti-inflammatory M2s also improved. “The sequencing is not yet completely clear,” comments Dr. Yu, “but it appears to be a closed-loop, feed forward, self-magnifying cycle.”

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