New potential diabetes treatment regenerates insulin-producing cells was written by Michael Irving for NewAtlas.com, 13 June 2022.
An emerging way to treat diabetes is to repair or replace the cells in the body that naturally produce insulin. Swedish researchers have now identified a molecule that helps stimulate the growth of new insulin-producing cells, and uncovered how it works, opening up new potential diabetes treatments. An emerging branch of study centers on finding ways to replenish the insulin production of those beta cells. Previous breakthroughs have included creating artificial beta cells that can pick up the slack, or using stem cells to grow new ones.
In the new study, researchers at the Karolinska Institutet in Sweden examined a small molecule that may help regenerate beta cells. The molecule, known as CID661578, was identified in previous work, but how exactly it worked and to what extent remained unknown.
“Our findings indicate a new potential target for treating diabetes, in that we demonstrate a possible way of stimulating the formation of new insulin-producing cells,” says Dr. Olov Andersson, the last author of the study. “We’ll now be studying the effect of this and similar molecules in human tissue and analyzing the molecule’s target protein, MNK2, in tissue from healthy donors and donors with diabetes.”
Senseonics’ glucose monitoring system receives CE mark, posted by MedicalDevice-network.com, 17 June 2022.
Senseonics has obtained CE mark approval for its next-generation Eversense E3 continuous glucose monitoring (CGM) System, which can be used for up to six months. The system is intended to continually measure glucose levels in people aged 18 years and above with diabetes.
Eversense E3 offers patients a fully implantable third-generation sensor that uses proprietary sacrificial boronic acid (SBA) technology to boost sensor longevity. It has a sensor wear duration of six months, making the device the longest-lasting CGM sensor available. It also has a removable smart transmitter, which offers on-body vibratory notifications and transmits data to a mobile application that displays glucose values, trends and alerts.
With the approval, Eversense E3 will be marketed in Germany, Italy, Spain (including Andorra), the Netherlands, Poland, Switzerland, Norway, and Sweden.
A new diabetes implant will help you control therapy with a piezoelectric button was reported by Deena Theresa for InterestingEngineering.com, 15 June 2022.
A new concept could unlock an entirely new level of convenience for patients to control their therapies — cell-based ones, in this case. Scientists at the Department of Biosystems Science and Engineering, ETH Zurich, Switzerland, have devised a self-sufficient push-button device that contains engineered human cells that can be implanted directly under the skin, according to a new study published in the journal Science Advances.
In other words, the key to a healthy life with Diabetes could be skin-deep, after all. As a proof of concept, the researchers showed that finger-pressure activation of the implant could restore normal sugar levels in a mouse model of type 1 diabetes.
“It is a quantum leap for merging electronics with genetics and kick-off for real-world therapeutic applications. The push-button has the power to program genetic activities of cells by electricity to an all-new level,” Martin Fussenegger, researcher and Professor of Biotechnology and Bioengineering, said.
Complicated but read more: A new diabetes implant will help you control therapy with a piezoelectric button
Every human and animal on earth needs insulin to survive and thrive. For those without diabetes, the pancreas efficiently pumps out the amount of insulin required to keep blood glucose levels normal around the clock, constantly adjusting in response to numerous variables, like meals or stress.
Is there something different about using exogenous insulin injections, as opposed to the insulin produced by the healthy human body, that will cause people to gain undesirable weight? In theory, as we said above, exogenous insulin injections shouldn’t cause excess weight gain unless you are also eating too much food. The reality may be more complicated.
Read more: Does Insulin “Make” You Fat?
Lager beer improves gut health in men was posted by Ameya Paleja for InterestingEngineering.com, 15 June 2022.
A study conducted by researchers at NOVA University in Lisbon has shown that lager beer, when consumed in moderation, improves the gut health in men and thereby reduces the risk for certain diseases. The study was published today in the ACS Journal of Agricultural and Food Chemistry.
Previous studies have shown some health benefits of drinking wine in moderation. These benefits have been attributed to polyphenols in the drink. Polyphenols are a class of micronutrients that occur naturally in plants and, along with other compounds found in foods, serve as antioxidants in the body.
Based on their findings, the researchers suggest that drinking beer every day might be good for intestinal health. Since alcohol consumption has documented side effects, the researchers recommend opting for non-alcoholic beers to maximize benefits.
Read more: Lager beer improves gut health in men
The best exercise time is different for men and women was reported by Bobby Berman for MedicalNewsToday.com, 14 June 2022.
A new study suggests the time of day at which a person exercises may produce different results. In addition, those results are not the same for women and men. Professor Paul J. Arciero, lead author of the study and professor at the Health and Human Physiological Sciences Department at Skidmore College in New York, says that the best time for exercise is when people can fit it into their schedules. Nonetheless, the study reveals certain time periods when individuals are most likely to achieve specific exercise goals. The study was published in Frontiers in Physiology.
One of the unique aspects of the study is its exploration of exercise time of day on mood. “For the first time, we show that exercise time of day significantly alters mood state in women and men,” Dr. Arciero said. “Specifically, women who exercise in the p.m. significantly boost overall mood state compared to those exercising in the morning.”
Dr. Asad R. Siddiqi, assistant professor of physical medicine and rehabilitation at , pointed out another interesting finding: “The men studied had greater improvement in perceived mood state than women. Exercise seemed to decrease tension, depression, anger, substantially in men regardless of the time of day, whereas improvements in tension and depression were only seen in women who exercised at night.”
He added that studying mood is inherently more difficult due to its reliance on self-reporting.
- Women who exercised in the morning reduced more total fat and abdominal fat, lowered their blood pressure to a greater degree, and increased lower body muscle power.
- Women who exercised in the evening saw more improvement in their upper body muscle strength, mood, and satiety.
The effect was less pronounced in men. However, there were differences:
- Men who exercised at either time of day improved their physical performance.
- Men who exercised in the evening saw benefits in heart and metabolic health, as well as lower fatigue.
Medical device companies to curb spending as recession threat clouds longer-term outlook was contributed by Nick Paul Taylor for MedTechDive.com, 13 June 2022.
Medical device companies, especially smaller businesses, likely will curb spending in the second half of the year as they prepare for a potential recession amid rising inflation and as supply chain and staffing woes continue, according to analysts at RBC Capital Markets and William Blair.
That’s as a clearer picture has emerged of the impact of macro trends for medical device companies from the second quarter and beyond, analysts at both companies said in notes to investors. Macro trends such as supply chain constraints, inflation, and hospital staffing shortages have shaped the performance of medical device companies since the second half of last year.