Here’s an interview by Monica Westley, of TheSugarScience, with Dr. Hans Sollinger, MD, PhD, Founder & Interim CSO of Endsulin. Dr. Sollinger has been a leader in diabetes care for decades and has revolutionized the field twice. Endsulin is overcoming the limitations of today’s taxing diabetes treatments with a patented gene construct and simple process that re-engineers part of the liver, allowing it to produce and regulate insulin on its own. 

I’m sharing a lot of information because it seems VERY exciting!  What do you think?

With an astoundingly simple process, their patented gene construct, built on decades of research at the UW Hospitals and Clinics in Madison, may allow patients to precisely regulate insulin on their own by re-coding a small fraction of their liver to function like a pancreas. The potentially long-lasting effects could free millions of people from the cumbersome daily management of their disease.

    • GENE THERAPY BECAUSE IT’S MINIMALLY INVASIVE AND DURABLE:  Gene therapy is one of the most promising emerging biotechnologies, because it can cure patients for a prolonged period of time. For instance, patients receiving gene therapy treatments for hemophilia have been cured for 10 years with one treatment.  Treatment is easier on patients, and long-lasting.
    • GIRE: ENDSULIN has developed a patented DNA sequence called glucose-inducible regulatory element (GIRE). It responds to glucose concentrations in the blood, then provides regulated release of insulin to accomplish blood-glucose control.  Animal experiments have achieved this type of control for the life of the animal.  It can achieve near-perfect regulation.
    • AAV8 BECAUSE IT’S EFFICIENT:  GIRE is packaged inside adeno-associated virus (AAV), which is not known to cause disease, but can still transfer the gene to the liver cells. AAV8 has a long-term safety record, and the FDA has approved more than 100 AAV trials.  It only takes one treatment.
    • HEPATOCYTES, BECAUSE THEY CAN ALREADY REGULATE GLUCOSE: A major advantage of hepatocytes is that they can effectively produce peptides, including insulin.  The liver already has regulatory elements that, with the addition of our unique GIRE, assist in maintaining normal glucose levels. The genetically altered hepatocytes mimic the action of a normal pancreas.  Because hepatocytes don’t carry proteins on their surface (which are the target of the autoimmune disease that causes diabetes), there is no risk the autoimmune system will destroy the genetically altered hepatocytes. 
    • TARGETED, TO MITIGATE RISK:  The therapy exclusively targets a small portion of cells so it doesn’t interrupt the liver’s regular functioning. For the treatment to work, only one in 50 liver cells need to be transduced. 
    • CLEAR REGULATORY PATH: The AAV vector has the best chance to pass regulatory hurdles, since the only FDA-approved gene therapies at this time are based on AAV
    • SCALABILITY: Process development and scale-up procedures for AAV8 are already well-established.  AAV8 allows for long-term storage and easy shipping.

Read more:  Endsulin

Runner nears finish of Disneyland to Disney World run — undeterred by pandemic pause was reported by Brady Macdonald for, 3 April 2021. The Type 1 diabetic will complete his Mouse-to-Mouse run on Monday, April 5 at the Magic Kingdom in Florida — barring any other cataclysmic world-changing events. The Mouse-to-Mouse run within a run is part of Muchow’s larger Run Across America intended to empower people with Type 1 diabetes to walk, run or ride. 

Don Muchow was determined nothing would stop his 2,761-mile cross-country run from Disneyland to Walt Disney World — not the blisters on his feet, his Type 1 diabetes or the once-in-a-century COVID-19 pandemic. Muchow will complete his Mouse-to-Mouse run on Monday, April 5 at the Magic Kingdom in Florida — barring any other cataclysmic world-changing events.

“I never considered quitting even once,” said Muchow, 59, of Plano, Texas. “COVID didn’t change my mission: I want every single person with Type 1 diabetes to see that we can still dream big, despite the very real 24/7 challenges and risks involved in balancing insulin, blood glucose, food and activity.”

Read more: Runner nears finish of Disneyland to Disney World run

Navy SEALs Use a Technique Called “Box Breathing” to Relieve Stress and So Can You, written by Erin Bunch for, 4 April 2021.  

Even as hope appears on the horizon with respect to the COVID-19 pandemic now that vaccine rollout is ramping up, Americans remain besieged by unprecedented anxiety. As such, your personal threshold for stress is probably lower right now, which means you may find yourself going from zero to panic in mere moments. To combat this overwhelm, it’s helpful to have a number of tools on tap—and you’d be hard-pressed to find one with a better endorsement than box breathing, a calming technique used by elite U.S. Navy SEALs.

Box breathing is rooted in an Ayurvedic form of breathwork called pranayama that originated in India and is practiced in yoga, explains Tal Rabinowitz, founder and CEO of The DEN Meditation in Los Angeles. “It has incredibly ancient roots, with different techniques for calming, bringing in energy, refining focus, and relaxing the nervous system; however, the military popularized it and brought it mainstream,” she says. “Mark Divine, a former Navy SEAL who is also a very experienced martial artist, introduced it to the special operations community in the military, showing the world that by simply breathing, you can achieve the desired calming effects in just moments.”

The practice itself, which gets its name because there are four equal parts to it, is super simple. It works on the principle that slowing down your breathing helps you to relax, increases your oxygen intake, releases tension, and stimulates the vagus nerve, which is the longest nerve in your body and starts in the brain. One of its main functions is to slow the sympathetic stress response, says Erika Polsinelli, a Kundalini yoga teacher and founder of Evolve by Erika, a virtual wellness center. She points out that some pilot research published in the journal, Brain Stimulation, shows that stimulating it may improve anxiety.

Read more:  Navy SEALs Use a Technique Called “Box Breathing” to Relieve Stress

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