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ADVOCATE: n. [ad-vuh-kit, -keyt]: a person who speaks or writes in support or defense of a person, cause, etc.

It’s really not very hard … and it’s really important. After all, who’s more important to your own life than you? It is survival.

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21th Annual Shooting Stars JDRF Walk to Cure Diabetes Sunday, October 23, 2016 in Newport Beach, CA at The Waffle House

For a contribution of $50 (or MORE!), walkers will receive a VERY COOL Shooting Stars Team T-Shirt while supplies last. Contact Joanne if you are interested in attending the event. joanne@TheSavvyDiabetic.com. To donate on-line, please go to: http://tinyurl.com/z5c2x8e.

Savvy Fun Fact: Highest-Paid Biopharma Execs

I just thought this was interesting.  It was published on FiercePharma.com, 11 July 2017.
Tracking executive pay follows a familiar pattern: Collect compensation disclosures, read said documents as they pile up, and when the usual suspects have all filed their annual reports and proxy statements, put the numbers into a spreadsheet and sort descending.
It’s pretty much guaranteed Johnson & Johnson’s CEO will be near the top of the list, regardless who’s in the job. Same for Abbott Laboratories—until it spun off its pharma business, AbbVie, whose CEO is now a regular. Same for Bristol-Myers Squibb—from Jim Cornelius to Lamberto Andreotti and now Giovanni Caforio, M.D.
Of note:
Alex Gorsky of Johnson & Johnson: $26.87m

John Lechleiter of Eli Lilly: $18.37m

Pascal Soriot of AstraZeneca: $17.40m

 

 

 

 
Read more: The top 15 highest-paid biopharma executives

Recipes for the Savvy D

Oh yum, here are some really good and interesting foods and recipes!

25 Beautiful Low Carb Blueberry Recipes, from ASweetLife.org … some great ideas. 
Blueberries are SO very good for you and also very low glycemic index. Here you go … some of the best blueberry recipes!
Read more: 25 Of The Best Low Carb Blueberry Recipes
 

 

 
Feel Light And Free With This Easy Cloud Bread Recipe, as reported on BuzzFeed by Alix Traeger, 6 May 2017.
Here are the ingredients:

3 eggs, separated
⅛ teaspoon cream of tartar
3 tablespoons softened cream cheese or Greek yogurt

Read more: Easy Cloud Bread Recipe

 

Fluffy Keto Pancakes, as shown on TheKetoCookbook.com. 
This recipe makes delicious keto pancakes that are as good as the real thing, light, fluffy and delicious! Serve them with either some crispy bacon, or topped with some peanut butter for a scrumptious keto breakfast.
Read more: Fluffy Keto Pancakes
 

 

Jes pancake cgm Jes pancake NS

And a great read from Jessica Ching with her recipe for The Dream Low-Carb Pancakes
Hi All,
I’m having a really (really!) great day and hope you are too.  Wanted to share my reason for the greatness.
Do you like pancakes but hate the spikes?  Take a look at the pancake breakfast I had at 8:45am this morning.
Then look at my Dexcom (or NightScout monitor, for those  of you who are interested) profile now.  Wow!!  I landed at BG110
There is a 2-part trick to this (and you DON’T need a closed loop system like mine to do it):

 Low carb pancakes
 A teeny over-bolus for the meal, but then shut off basal for 2 hrs after

 

 

 

 

 

 
Here’s the theory:
– As we know eating lower carb foods is easier for BG management. But sweets are sooo good! 
– Your body can […]

Savvy Updates, 7/8/2017: Novo Nordisk RECALL, Nasal Glucagon, ‘Smart’ Insulin Patch, ‘Smartmat’

Novo Nordisk recalls faulty cartridge holders in insulin pens was announced 5 July 2017. 
Novo Nordisk said it was initiating a recall of insulin cartridge holders used in some NovoPen Echo insulin pen devices distributed in the United States because the holders may crack or break if exposed to certain chemicals, including certain cleaning agents. Using a device with a cracked or broken cartridge holder could result in delivery of a smaller dose of insulin than expected, the company said. Separately, Novo Nordisk warned of a similar problem with NovoPen Echo and NovoPen 5 devices distributed in Canada.
Read more: Novo Nordisk Recalls Cartridge Holders In Certain Novopen Echo® Insulin Delivery Devices
 
Nasal Glucagon Fixes Severe Hypoglycemia in Type 1 Diabetes, as reported at the ADA 2017 Scientific Sessions in June, 2017 by researchers at the University of Minnesota School of Medicine.

Giving one puff of a dry glucagon powder inside the nose of an adult with type 1 diabetes who was having a moderate to severe hypoglycemic episode was easy for a caregiver to do and led to recovery within 30 minutes in almost all patients in a phase 3 study. The treated patients recovered from hypoglycemia within a half hour in 96% of cases, and 90% of the caregivers (typically a spouse) found the product easy to use, Elizabeth R Seaquist, MD, University of Minnesota School of Medicine, Minneapolis.
Read more: Nasal Glucagon Fixes Severe Hypoglycemia in Type 1 Diabetes
 
‘Smart’ insulin patches developed at UNC, NCSU one step closer to market, as published in The News & Observer, 30 June 2017.

Zhen Gu, whose team at the UNC-N.C. State Biomedical Engineering Program has been leading the effort to develop “smart” insulin patches for treating diabetes, co-founded a company […]

Savvy Updates 7/6/17: Vaccine, TetraGenetics, Cure for MS, Tissue-engineered islet transplant, Glucagon-blocker

Lots of research news these days … here are a few exciting ones!
MGH study shows vaccine could permanently reverse type 1 diabetes, as reported in the Boston Business Journal, 10 June 2017.  Researchers from Massachusetts General Hospital have discovered that a vaccine could permanently reverse the disease.
Dr. Denise Faustman, director of the Massachusetts General Hospital immunobiology laboratory and principal investigator of the trial, said interim results show that unlike other vaccines that irritate white blood cells to prompt an immune response, the BCG vaccine affects white blood cells at the genetic level, regulating which genes are expressed and which are not. The body consequently stops producing the abnormal white blood cells responsible for the autoimmune disease, suggesting that the vaccine could permanently reverse type 1 diabetes.
“The vaccine actually resets your genes to restore normality,” Faustman said in an interview. “What it is showing is it’s not merely the vaccine you’re being given and it causes inflammation or an immune response. It’s actually working at the most basic DNA level to normalize expression of genes related to this abnormal immune response.”
Read more: MGH study shows vaccine could permanently reverse type 1 diabetes
 
JDRF Invests in TetraGenetics’ Innovative Approach to Type 1 Diabetes Prevention was highlighted in ASweetLife.com, June 2017. 
A unique scientific approach to preventing, treating and, perhaps one day, curing type 1 diabetes is being coupled with JDRF’s equally innovative approach to funding such studies in a new partnership that might move the promise of a preventive therapy and improved treatment for the condition closer to reality.
The big picture view is that type 1 diabetes is an autoimmune disease, meaning that the body’s own immune system attacks insulin-producing beta cells in the pancreas, killing them and […]

SAVVY Happy 4th of July!

 

 
 
 

 

 

 

Just some patriotic D words!
RED
       READY for THE CURE! 

reaction
research
regular insulin
rapid acting insulin
retina
rebound hyperglycemia
renal threshold

WHITE
       WOW, DIABETES is challenging!

weight control
whole grains
wireless devices
 world diabetes day

BLUE
      BYE BYE Diabetes – #WeAreNotWaiting!

Blood sugar
Blood glucose meter
Blood pressure
Basal rate
Basal rate
BUN
Bolus
Brittle diabetes
Body mass index
Blood vessels

Got any other words????
 

 

 

Alert Dogs … How Do They Do That?!

Diabetes alert dogs are amazing! And very accurate! I was stunned when I attended an AADE conference and was watching the former Miss America, Nicole Johnson, signing her book for attendees, with her alert dog, Lucy at her side. Lucy is a golden doodle dog, absolutely adorable. All of a sudden, as Nicole was signing a book for a lady with diabetes, Lucy became agitated and put her paw on the lady. After trying to settle her down, Nicole checked her own CGM … she was fine. So she asked the lady to check … and indeed, the lady’s BG was 65! Lucy didn’t settle for about 10 minutes after the lady took some sugar. Then Lucy went back to being the perfect, obedient, calm dog. Nicole told me that when Lucy travels on the airplanes with her, sometimes Lucy reacts when another traveler has a low blood sugar! Amazing!!!

How do they do that???

In a study at Wellcome Trust-MRC Institute of Metabolic Science at the University of Cambridge, UK reported in Diabetes Care Journal, July 2016, scientists hypothesized that domestic dogs might sense a change in volatile organic compounds (VOCs) in exhaled breath. They studied 8 female non-smoking adult T1s under controlled conditions, lowering their blood sugar levels and looking for specific chemical signatures to detect the presence of certain molecules. They found that isoprene rose significantly during hypoglycemia. In fact, in some cases, the presence of isoprene nearly doubled.

Humans are oblivious to isoprene, but the researchers figure that dogs are particularly sensitive to the chemical, and can easily tell when their owner’s breath contains too much of it. As to why the body produces more isoprene during hypoglycemia, the researchers think it’s a […]

From DiabetesMine: Type 1 Diabetes Caregiver Confidence Book Review AND Giveaway!

Check it out!  My book review of Samantha Markovitz’s first book, Type 1 Diabetes Caregiver Confidence, chock full of advice and tools to help caregivers (grandparents, babysitters, neighbors, etc.) understand the basics of diabetes, treatments, emergencies … all packed into 128 very readable pages. 

 

 

 

 

 

DiabetesMine is offering to give away 2 free copies of this book!  Just go to the link below and leave a comment below the article, including the codeword, DMBooks … OR send in your entry to info@diabetesmine.com with the subject line, “T1D Caregiver.”  This offer is open until June 9, just a few days away!!!

Read more: “Type 1 Diabetes Caregiver Confidence” – Book Review with Giveaway!

Click here to BUY NOW!

DiabetesMine: Stuck Waiting for Medicare CGM Access

Mike Hoskins of DiabetesMine just posted: Stuck Waiting for Medicare CGM Access, about the saga of Medicare coverage (or not) of CGM, ever since their ruling to cover CGM was announced on 12 January 2017.  It’s been a rocky roller coaster for all Medicare-covered T1s trying to order their Dexcom G5 supplies.  And the end is not in sight. 

He cited my posts on this topic:
Another PWD caught up in this is our D-blogging friend Joanne Milo in California who writes at The Savvy Diabetic and has shed some light on a new ruling on this Medicare CGM coverage issue recently.
“The new article indicates that if Medicare beneficiaries use their Dexcom G5 with a smart phone, even if such use is in addition to using the receiver that comes with the Dexcom G5 system, all the CGM supplies will be non-covered,” she writes. “…This novel restriction appears to be designed to ensure that the only CGM that is covered by Medicare will not be covered for those individuals who use it to its full functionality to monitor their glucose levels.”
Read more: Stuck Waiting for Medicare CGM Access

Savvy Update, 5/29/2017: Fiasp, Senseonics, Apple, Nevada Law

Here are some great blog posts by Tim Street about his experiences and comments about the new faster-acting insulin, Fiasp.

 

 

 

 

 

48 hours with Fiasp. What are my first thoughts on Faster insulin Aspart?
My month with the newest kid on the block & a hypothesis on the #Fiasp effects

And from ASweetLife.com: Just How Quick is Fiasp, Novo Nordisk’s Faster-Acting Insulin?
 
Roche helps Senseonics raise $41M to push diabetes device, as reported in FierceBiotech, 5/26/2017. 
Senseonics is set to raise $41 million to support the anticipated commercialization of implantable continuous glucose monitoring (CGM) system Eversense. The fundraising attracted the support of major existing shareholders New Enterprise Associates (NEA) and Roche.
Senseonics’ is developing an implantable sensor. Once inserted by a doctor, the sensor uses fluorescence technology to measure glucose levels in the interstitial fluids. The sensor sends readings to a wearable patch that, in turn, processes the data and relays information to a smartphone app. Users are alerted when the technology forecasts glucose levels will exceed preset targets. The sensor lasts up to 90 days.
Read more: Roche helps Senseonics raise $41M to push diabetes device
 
Apple CEO Tim Cook Test-Drives a Blood Sugar Tracker, as reported by CNBC, 5/18/2017.
Tim Cook has been spotted at the Apple campus test-driving a device that tracks blood sugar, which was connected to his Apple Watch.  A source said that Cook was wearing a prototype glucose-tracker on the Apple Watch, which points to future applications that would make the device a “must have” for millions of people with diabetes — or at risk for the disease.
Read more: Apple CEO Tim Cook test-drove a device that tracks his blood sugar
 
 
Nevada bill could force Sanofi, Novo and Lilly to reveal their insulin pricing secrets, as reported […]

Cataracts? Yes, CATARACTS!

Wondering why I’m writing about cataracts?  I just had cataract and lens replacement surgery in both eyes over that past 2 months.  I’m now living with extreme clarity, vivid colors and total relief that it is done and I am healing well. 

I’m 63 and I’ve had T1D for over 52 years. When I realized that I was headed for cataract surgery, these thoughts kept rolling around in my head:

NO, I don’t want to deal with this!
I’m TOO YOUNG for this!
I’m scared … don’t mess with my eyes!
What if something goes wrong?

The first cataract ophthalmologist told me I could wait and only do one eye at a time.  He said I’d know when it was time … when I couldn’t see well enough while driving and when I couldn’t keep up with eyeglass lens replacements every 3-6 months.  I hit that point 4 months ago.  My optometrist said they couldn’t correct my vision much further.  BINGO … time to find out more and identify my surgeon.

 

Let’s understand more about cataracts.

What is a cataract?
A cataract is a clouding and/or yellowing of the lens in the eye that affects vision. Most cataracts are related to aging. 
 

What is the lens?
The lens is a clear part of the eye that helps to focus light, or an image, on the retina. The retina is the light-sensitive tissue at the back of the eye.
In a normal eye, light passes through the transparent lens to the retina. Once it reaches the retina, light is changed into nerve signals that are sent to the brain.
The lens must be clear for the retina to receive a sharp image. If the lens is cloudy from a cataract, the image you see will be blurred.
 

What causes cataracts?
The […]