I’ve been using Afrezza intermittently for the past 2 years … and am continually amazed at how well and how fast it works!
What is Afrezza? Developed by Al Mann (who also developed the insulin pump and the cochlear hearing implat, among many other great advances – see a tribute to him in my blog archives), Afrezza is the only inhalable insulin available on the market today.
Afrezza is dried human insulin produced in a lab from recombinant DNA. The powder is placed into carrier particles (called Technosphere particles) that are so small that once inhaled they can reach your deep lungs, which have the surface area of about half the size of a tennis court.
Just take a moment and visualize one side of a tennis court … that’s the amount of surface that is reached when you inhale Afrezza into your lungs.
It comes in 4-unit, 8-unit and 12-unit cartridges, which equate, roughly, to 2.5U, 5U and 7.5U of liquid fast-acting insulin.
But there are very distinct advantages:
Enhanced absorption: this is due to the very large, accessible surface area within the alveoli of the lungs
Rapid onset of action: Since the lung tissue consists of a large alveoli-capillary network, protein molecules such as insulin cross a thin barrier formed by the alveolar wall and the capillary wall, allowing for rapid delivery into the bloodstream. Indeed it starts working within 10 minutes of inhaling and is mostly out of your system within 2 hours (as opposed to injectable insulin with an onset of 1/2 hour and duration up to 4 hours)
Absence of digestive enzymes that can inactivate insulin
On the downside:
About 1/4 of patients using Afrezza have reported a cough
Some decline in pulmonary function
My take on using Afrezza:
I think Afrezza […]