Relationship between the composition of the gut microbiome and diabetes is being demonstrated repeated in studies, as reported in Endocrinology Advisor by Tori Rodriguez, August 11, 2016.
In a twin study by researchers at Harvard Medical School, MIT and Seoul National University in South Korea, published in 2016, there is an altered function and composition of the gut microbiome with biomarkers of subclinical T2 diabetes. Among other systems and processes, microbiota has effects on the immune system, which indicates that it alters inflammatory markets and T cell subset regulation. A shift in immune response is significant as it applies to T1 diabetes and may be of particular interest for T2 diabetes. Indeed, as previous research has shown, “while the microbiome of healthy infants becomes more stable and diverse as they approach toddlerhood, the microbiome of those at high risk of autoimmunity become less stable and diverse, which could result in distinct differences in the autoimmune microbiome between healthy children and those with type 1 diabetes.”
The gut microbiome may increase understanding of the pathogenesis of type 1 and type 2 diabetes.
“The development of type 1 diabetes seems to be associated with a reduced bacterial diversity in the gut, and this phenomenon appears after seroconversion to positivity for diabetes-associated autoantibodies,” says study co-author Mikael Knip, MD, PhD, professor of pediatrics at the University of Helsinki in Finland. “This indicates that the dysbiosis may be involved in the progression from autoantibody positivity to overt disease but not with the initiation of beta-cell autoimmunity,” he said. Additionally, those who progress to type 1 diabetes show a reduced number of beneficial bacteria and an increased number of bacteria with pathogenic potential.”
Read more: Role of the Gut Microbiome in Diabetes
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