Antibiotics Linked to T1D in Mice, according to a study at NYU Langone Medical Center, reported in Nature Microbiology, August 22, 2016 and published in MedPageToday, Endocrinology, August 24, 2016. The study results center on the microbiome, the bacterial species in our guts that co-evolved with humans to play roles in digestion, metabolism, and immunity. As children’s exposure to microbe-killing antibiotics has increased in recent decades, the incidence of autoimmune diseases like type 1 diabetes has more than doubled. The average American child currently receives 10 courses of antibiotics by age 10.
Specifically, the new study found that short pulses of antibiotics cause mice that are susceptible to type 1 diabetes to develop the disease more quickly and more often than mice not treated with antibiotics.
“Our study begins to clarify the mechanisms by which antibiotic-driven changes in gut microbiomes may increase risk for type 1 diabetes,” says Martin Blaser, MD, The Muriel G. and George W. Singer Professor of Translational Medicine at NYU School of Medicine and the study’s senior author. “This work uses NOD mice, the best model of type 1 diabetes to date, and doses of antibiotics like those received by most children to treat common infections.”
‘This latest study result is compelling, linking the effects of use of antibiotics in mice to type 1 diabetes,” says Jessica Dunne, director of Discovery Research at JDRF who funded this research. “This is the first study of its kind suggesting that antibiotic use can alter the microbiota and have lasting effects on immunological and metabolic development, resulting in autoimmunity.”
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